bstance P (SP) and its cognate Neurokinin receptor 1 (NK1R) are tachykinergic neuroinflammatory mediators widely expressed in the central nervous system, peripheral nervous system, enteric nervous system, and immune cells. The SP/NK1R pathway is activated by several noxious stimuli and triggers a sustained inflammatory response by inducing cytokines release from different cell subtypes. In Parkinson's disease (PD), SP colocalizes with α-synuclein in the central and peripheral structures more prone to degeneration, mostly within the gastrointestinal–nervous ascending system, suggesting a potential role in the disease pathogenesis through inflammation-related mechanisms.
Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction / Schirinzi, Tommaso; Maftei, Daniela; Grillo, Piergiorgio; Bovenzi, Roberta; Bissacco, Jacopo; Simonetta, Clara; Mascioli, Davide; Zenuni, Henri; Cerroni, Rocco; Vincenzi, Martina; Maurizi, Riccardo; Passali, Francesco M; Di Girolamo, Stefano; Ralli, Massimo; Magliulo, Giuseppe; Tirassa, Paola; Stefani, Alessandro; Mercuri, Nicola B; Lattanzi, Roberta; Severini, Cinzia. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - (2023). [10.1002/mds.29433]
Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction
Maftei, DanielaSecondo
;Grillo, Piergiorgio;Mascioli, Davide;Vincenzi, Martina;Maurizi, Riccardo;Ralli, Massimo;Magliulo, Giuseppe;Stefani, Alessandro;Lattanzi, RobertaPenultimo
;
2023
Abstract
bstance P (SP) and its cognate Neurokinin receptor 1 (NK1R) are tachykinergic neuroinflammatory mediators widely expressed in the central nervous system, peripheral nervous system, enteric nervous system, and immune cells. The SP/NK1R pathway is activated by several noxious stimuli and triggers a sustained inflammatory response by inducing cytokines release from different cell subtypes. In Parkinson's disease (PD), SP colocalizes with α-synuclein in the central and peripheral structures more prone to degeneration, mostly within the gastrointestinal–nervous ascending system, suggesting a potential role in the disease pathogenesis through inflammation-related mechanisms.| File | Dimensione | Formato | |
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